Investigation of the internal structure of thermoresponsive diblock poly(2-methyl-2-oxazoline)-b-poly[N-(2,2-difluoroethyl)acrylamide] copolymer nanoparticles

•Internal structure of the thermoresponsive copolymer nanoparticles was elucidated.•Number of complementary physico-chemical methods were employed.•Internal structure was correlated with the properties critical for biomedical uses.