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Prognostic Impact Of Notch Signaling In Acute Myeloid Leukemia (Aml)

Paul Takam Kamga,Federica Resci,Giada Dal Collo,Annalisa Adamo,Riccardo Bazzoni,Angela Mercuri,Massimiliano Bonifacio,Mauro Krampera

BLOOD（2018）

Cited 3|Views8
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Abstract
Background: Notch signaling is a developmental pathway involved in normal and malignant hematopoiesis. Mutations in Notch genes lead to T-ALL and are associated with poor prognosis in B-CLL. However its role in AML is still under investigation, with controversial results. In addition, although the pathway consists of 4 receptors and 5 ligands, many studies are mostly based on single receptor or ligand.
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Key words
acute myeloid leukemia,notch signaling,aml,prognostic impact
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