Myc Regulates The Development And Anti-Tumor Immunity Of Natural Killer Cells

Natural Killer (NK) cells play an essential role in the innate immunity. We recently reported that in aggressive NK cell leukemia, MYC is hyperactivated and responsible for the survival and proliferation of leukemic cells through the activation of JAK/STAT pathway (Huang et al., Cell Research 2017). However, the role of Myc in normal NK cell development or function has not been fully explored. Here we addressed the important question on whether Myc is required for NK cell development and its anti-tumor immunity.