Modulation Of Nk, T, & B Cell Subpopulations By Pomalidomide Predicts Favorable Progression-Free Survival (Pfs): Results From A Large Randomized Clinical Trial In Relapsed/Refractory Myeloma

Modulation of NK, T, & B cell sub-populations by Pomalidomide predicts favorable progression-free survival (PFS): Result assessment of these mice will determine if efficacy remains equivalent long term. Invariant natural killer T-cells (iNKTs) harbor innate and adaptive immune cell properties and do not cause GvHD so are potentially useful in an allogeneic setting as an" off the shelf” CAR product. They may also offer reduced risk of CRS and neurotoxicity compared to CAR-Ts. We generated CS1-iNKTCARs which killed MM. 1S-CG targets in Chr51 assays. We have gene edited CS1 from these cells (CRISPR/Cas9) and are assessing fratricide and efficacy. Together, we have generated highly effective CAR-T cells targeting CS1. Future experiments are aimed at comparing CS1-CAR-T vs CS1-iNKT-CAR with and without CS1 gene editing. Our work further validates the utility of CS1 as an immunotherapeutic target …