An Efficient Protocol For The Synthesis Of Pyrido[2,3-D]Pyrimidines In Glycerol-Water Medium: Assessment By Green Chemistry Metrics

A clean and ecofriendly approach for the catalyst-free synthesis of pyrido[2,3-d]pyrimidine derivatives by one-pot three-component condensation of aromatic aldehyde, malononitrile and 6-aminouracil or 6-amino-1,3-dimethyluracil using glycerol-water (3:1) as green reaction media has been developed. Catalyst-free synthesis with high to excellent yields and use of glycerol-water system as an environmentally benign reaction condition are the prominent features of this strategy. Moreover, excellent outcomes from the calculations of green chemistry metrics reveal the greenness of the protocol.