Applicability of a modified breakage and coalescence model based on the complete turbulence spectrum concept for CFD simulation of gas-liquid mass transfer in a stirred tank reactor

•The Original model over-predicts bubble sizes since it considers only the sub-range of turbulence scales.•The Complete Energy cascade improves the accurate in gas-liquid CFD-PBM models.•Hybrid geometries (axial-radial flow patterns) increase simulated kLa in a stirred bioreactors.