Fully Automated Preparation Of Ga-68-Psma-11 At Curie Level Quantity Using Cyclotron-Produced Ga-68 For Clinical Applications

Ga-68-PSMA-11 is currently one of the most investigated PET agents for imaging both recurrent prostate cancer and relevant metastases; however, the production and distribution of Ga-68-PSMA-11 is limited to a supply of only a few daily doses when using a commercially available Ge-68/Ga-68 generator. Ge-68/Ga-68 generators deliver only a modest amount of activity, up to 1850 MBq (50 mCi), when new, but it decreases with time. Additionally, the production of Ga-68/Ge-68 generators has not been able to meet the increasing demand of Ga-68 radiotracers. In response to the need for a more economically viable alternative, the focus of this study was to provide a simple and efficient method for producing Ga-68-PSMA-11, using cyclotron-produced Ga-68 that is ready for routine clinical practice.