Mechanism Of Action Of An Autovaccine Against Canine Dlbcl Lymphoma Leading To A Long Overall Survival

An autovaccine against canine DLBCL lymphomas associated to a CHOP protocol has proven to greatly improve the overall survival and the time to progression of a series of dogs against another series only treated by the CHOP protocol (1). This vaccine was obtained by purifying specific proteins and peptides from a node biopsy. In order that the vaccine matches the heterogeneity of the tumor, one vaccine was produced for each dog.