Structural Variations Identified By Whole Transcriptome Sequencing (Rna-Seq) In Childhood All With Different Response To Therapy

Introduction. Acute Lymphoblastic Leukemia (ALL) is the most frequent type of childhood leukemia. It is a multi-step process, characterized by the expansion of a pre-leukemic clone, accumulating cooperative genetic events required for the full transformation and clinical manifestation. Recently, the technological advances in genome-wide profiling techniques have allowed a better understanding of its molecular basis and heterogeneity. However, incidence and cure rates greatly differ among children, reflecting diverse responses to drug treatment and distinguishing risk groups. This defines the need for molecular investigations to better understand leukemia biology and improve risk prediction.