Abstract 16596: Dominant Mouse Mutagenesis Screen Unveils a Complex Genetic Architecture for Congenital Heart Disease

Michael Wang,Tuantuan Tan,Sara Hildebrand,Abha S. Bais,Sebastian Ho, Yiming Wang,Daniel Sonnenberg, Manisha Kukkillaya, Caleb Radomile, Lauren Meyer,William A. Devine,Laura G. Reinholdt,Bruce Beutler,Yijen L. Wu,Cecilia W. Lo

Circulation（2018）

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摘要

Introduction: Human studies show congenital heart disease (CHD) has a complex non-Mendelian genetic etiology. We previously conducted a recessive N-ethyl-N-nitrosourea (ENU) mouse mutagenesis scree...

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关键词

congenital heart disease,heart disease,complex genetic architecture,mouse

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