Atenolol thiourea hybrid as potent urease inhibitors: Design, biology-oriented drug synthesis, inhibitory activity screening, and molecular docking studies
Bioorganic Chemistry(2020)
Abstract
•Biology-oriented drug synthesis (BIODS) of new thiourea analogs of drug atenolol.•Structural characterization by various spectroscopic techniques.•Evaluation for their urease inhibitory activity.•Amongst all compounds, compound 22 was the most potent urease inhibitor.•Molecular docking was done to decipher various important mode of interactions.
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Key words
Biology-oriented drug synthesis (BIODS),Atenolol,Thiourea,Urease,In vitro,Molecular docking study
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