Effects of different concentrations of desflurane on the index of cardiac electrophysiological balance in gynecologic surgery patients

The objectives were to observe the effects of different concentrations of desflurane on QT, QTc, Tp-e, Tp-e/QT, and the index of cardiac electrophysiological balance (iCEB). Sixty patients were randomly divided into group D-1, group D-2, and group D-3 by using a random number table, 20 in each group. After entering the operating room, patients received 10 mL/kg hydroxyethyl starch, 0.1 mg/kg midazolam, 0.1 mg/kg vecuronium, 3 mu g/kg fentanyl, and 0.3 mg/kg etomidate intravenously and then accepted intubation and mechanical ventilation. The desflurane evaporator was opened. The concentrations of desflurane in the D-1, D-2, and D-3 groups were maintained at 0.6, 1.3, and 2.0 minimum alveolar concentration (MAC), respectively. Twelve-lead ECGs were recorded at time before induction (T-1) and at 20 min after desflurane reached the required concentration (T-2). HR and MAP were recorded measure and the QT interval, QTc interval, Tp-e interval, Tp-e/QT ratio, and iCEB were calculated. Compared with before inhalation (T-1), the QTc interval was prolonged in the D-1, D-2, and D-3 groups after inhalation of different concentrations of desflurane for 20 min (T-2) (P < 0.05) and the Tp-e/QT ratio decreased in the D-1 and D-2 groups at T-2 (P < 0.05). Compared with the D-1 and D-2 groups, the Tp-e/QT ratio of the D-3 group increased at T-2 (P < 0.05). There was no significant difference in Tp-e interval and iCEB at any time (P > 0.05). The study suggested that inhalation of desflurane at a normal concentration cannot cause arrhythmogenic characteristics and affect the cardiac electrophysiological stability.