Potassium Salt of Fullerenylpenta-N-Dihydroxytyrosine Effects on Type 2 Diabetes Mellitus Therapeutic Targets

Yu. V. Soldatova,R. A. Kotelnikova,A. V. Zhilenkov,I. I. Faingold,P. A. Troshin,M. A. Kozlova,D. A. Areshidze, S. M. Aldoshin

Doklady Biochemistry and Biophysics（2019）

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摘要

It was shown for the first time that pentaamino acid derivative of fullerene C 60 (potassium salt of fullerenylpenta-N-dihydroxytyrosine) affects three targets of type 2 diabetes mellitus. It competitively inhibits the enzymes aldose reductase and sorbitol dehydrogenase and also has an antiglycation effect on bovine serum albumin. The inhibition constants for these enzymes were calculated.

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