Loss of PTPN23 Promotes Proliferation and Epithelial-to-Mesenchymal Transition in Human Intestinal Cancer Cells.

Lisa van der Lely,Janine Häfliger,Ana Montalban-Arques,Katharina Bäbler,Marlene Schwarzfischer,Max Sabev,Claudia Gottier,Silvia Lang,Michael Scharl,Marianne R Spalinger

Inflammatory intestinal diseases（2019）

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摘要

Our data clearly indicate that loss of PTPN23 is associated with increased activation of pro-oncogenic signaling pathways and an enhanced ability of human intestinal cancer cells to undergo EMT. Taken together, these findings show that PTPN23 acts as a tumor suppressor gene in CRC.

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关键词

Colorectal cancer,EGF receptor,Epithelial-to-mesenchymal transition,Growth factor signaling,Protein tyrosine phosphatase

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