Determination and pharmacokinetic study of skimmin by UHPLC-MS/MS in rat plasma.

Yan Lou,Hongyu Wu,Jinqi Zheng,Xiaoying He,Zhe Wu,Xiaoyang Lu,Yunqing Qiu

Journal of Pharmaceutical and Biomedical Analysis（2020）

引用 8|浏览5

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摘要

•First report on the quantification of skimmin in biological matrix.•UHPLC-MS/MS method was validated as per ICH and FDA guidelines.•The method was successfully applied to pharmacokinetic study.•The absolute bioavailability of skimmin was 25.08 %.

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关键词

ESI,ISR,IS,LOD,LLOQ,ME,RE %,RSD %,SD,UHPLC-MS/MS,MRM

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