An immunocompetent rat model of infection with Cryptosporidium species: Cryptosporidium hominis and Cryptosporidium parvum.

Denise Ann Dayao,Abhineet Sheoran, Alison Carvalho, Hongbin Xu,Gillian Beamer,Giovanni Widmer,Saul Tzipori

International Journal for Parasitology（2020）

引用 7|浏览8

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摘要

•Cryptosporidium spp. sporozoites infect the tracheal epithelium of healthy rats.•Intra-tracheal (IT) infection stimulates an immune response.•Primary infection of the tracheal mucosa protects against secondary challenge.•A rat IT model can be used to screen vaccine candidates for cryptosporidiosis.

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关键词

Cryptosporidiosis,Animal model,Intratracheal infection,Sporozoites,Vaccine,Immunity

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