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Downregulation of STAT1 induces the differentiation of neural stem cells through JNK pathway.

Yigang Liu,Min Yu,Dudu Jiang

Tissue and Cell（2019）

Cited 2|Views5
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Abstract
•Downregulation of STAT1 inhibited the proliferation of neural stem cells (NSCs).•STAT1 regulation controlled the differentiation of NSCs, mediated by the JNK/STAT1 signaling.•STAT1 inhibitor promoted differentiation of NSCs.•After transplantation, more neurons generated from NSCs with shRNA-STAT1 treatment.
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Key words
STAT1,Neural stem cells,Differentiation,Neurons
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