Leydig cell tumorigenesis - implication of G-protein coupled membrane estrogen receptor, peroxisome proliferator-activated receptor and xenoestrogen exposure. In vivo and in vitro appraisal.

E Gorowska-Wojtowicz,M Duliban,M Kudrycka, P Dutka,P Pawlicki,A Milon,M Zarzycka,W Placha,M Kotula-Balak,A Ptak, J K Wolski,B Bilinska

Tissue and Cell（2019）

Cited 18|Views13

No score

Abstract

•In mouse testes with Leydig cell tumor expression of GPER and PPAR is altered.•Treatment of MA-10 cells with BPA and its derivatives effects on GPER and PPAR expression.•There is a relation between expression of INSL3 and RLN and estrogen level in Leydig cell tumor.•PI3K-Akt-mTOR pathway and/or only mTOR is involved in GPER and PPAR interaction.

Translated text

Key words

Bisphenol A,G-protein coupled estrogen receptor,Insulin-Like peptides,Estrogen,Peroxisome proliferator-activated receptor,Leydig cell tumor

AI Read Science

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Chat Paper

Summary is being generated by the instructions you defined