The protective role of estrogen and its receptors in gentamicin-induced acute kidney injury in rats.

Sayed M Abd El-Lateef,El-Sayed M El-Sayed,Ahmed M Mansour,Salama A Salama

Life Sciences（2019）

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摘要

•Gentamicin induced acute kidney injury.•Megalin is implicated in gentamicin-endocytosis.•Genistien and estradiol ameliorated gentamicin-induced acute kidney injury.•Fulvestrant exaggerated gentamicin-induced acute kidney injury.

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E2,ERs,AKI,OVX,Kim-1,LDH,GGT,FITC-BSA,IHC,PTECs,LDL,ERE,DR,SP1,AP-1,TRE,LRP-2,BUN,GPR30,AF1,AF2,ChIP-seq

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