New metabolites from a Mariana Trench-derived actinomycete Nocardiopsis sp. HDN 17-237

One new beta,gamma-butenoate derivative phenylbutenote (1), and one new alpha-pyrone nocapyrone T (2) were isolated from the deep-sea derived actinomycete Nocardiopsis sp. HDN 17-237. Their structures were elucidated by extensive HRMS, IR and NMR analyses. Among them, compound 1 is the first microbial natural products bearing a rare beta,gamma-butenoate moiety, and compound 2 is the first alpha-pyrone isolated from strain of Mariana Trench. Compounds 1 and 2 were tested for antioxidant and antibacterial activities, while none of them showed significant activity.