Deletion of the SAPS1 subunit of protein phosphatase 6 in mice increases radiosensitivity and impairs the cellular DNA damage response.

Jaroslaw Dziegielewski, Magdalena A Bońkowska,Ewa A Poniecka,Jinho Heo,Kangping Du, Rowena B Crittenden,Timothy P Bender,David L Brautigan,James M Larner

DNA Repair（2020）

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摘要

•SAPS1, a regulatory subunit of the protein phosphatase 6 has been deleted in mouse.•SAPS1 null mice and cells do not show any gross defect in growth and development.•SAPS1 null mice and cells show defect in DNA repair and are sensitive to DNA damaging agents.

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关键词

Radiosensitivity,Protein phosphatase 6,SAPS1,DNA damage response

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