Alagille Syndrome and Chronic Arthritis: An International Case Series.

Giovanna Ferrara,Teresa Giani,Scott M Lieberman, Courtney Kremer,Sandy Hong,Giuseppe Indolfi,Grant Schulert,Randy Q Cron,Melissa L Mannion,Sivia Lapidus,Wineke Armbrust,Emmanuel Gonzales,Emmanuel Jacquemin,Isabelle Koné-Paut,Rolando Cimaz

The Journal of pediatrics（2019）

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摘要

We describe 10 children with Alagille syndrome and inflammatory arthritis. In our centers, the prevalence of chronic arthritis in patients with Alagille syndrome is approximately 50 times higher compared with the general population. Arthritis was refractory to most treatment. Patients with Alagille syndrome should routinely be screened for musculoskeletal symptoms.

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