FGL2 regulates IKK/NF-κB signaling in intestinal epithelial cells and lamina propria dendritic cells to attenuate dextran sulfate sodium-induced colitis.

•We verified the protective effect of FGL2 on IBD.•We first found that FGL2 has a function of inhibiting NF-κB activation in a model of IBD.•We first confirmed the effect of FGL2 on NF-κB signaling in IECs.•We found FGL2 could regulate the maturity of colonic LPDCs in DSS-induced colitis.