高血压大鼠心肌2型小电导-Ca2+-激活-K+通道蛋白(SK2)表达的变化
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology(2019)
Abstract
目的:观察高血压大鼠心肌细胞2型小电导-Ca2+-激活-K+(SK2)通道蛋白表达情况.方法:12只健康成年雄性SD大鼠随机分为对照组(5只)和实验组(7只),实验组采用N'-硝基-L-精氨酸(L-NNA 15 mg/(kg·d))腹腔注射制备高血压模型,对照组以等体积生理盐水腹腔注射,每天称量大鼠体重,每周测量血压及心电图变化,4周后处死大鼠取心脏;采用Western blot的方法检测心肌SK2通道蛋白表达水平.结果:给药4周后,与对照组相比,实验组大鼠血压明显升高(P<0.05),心电图QRS时长和R-R间期延长,实验组大鼠心房组织和心室组织SK2通道的表达均明显升高(1.12±0.18 vs 0.52±0.99,1.64±0.26 vs 0.99±0.22,P<0.05).结论:高血压模型大鼠心房和心室SK2通道表达增加,其可能是导致高血压模型大鼠出现心律失常的机制之一,为高血压疾病的治疗和预后提供新的思路和策略.
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Key words
hypertensive rat myocardium,channel protein
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