Absolute Structure And Anti-Oxidative Activity Of Chaetochiversin C Isolated From Fungal Strain Neocosmospora Sp. Fki-7792 By Physicochemical Screening

A new chaetochiversin analog, designated chaetochiversin C (1), was discovered from a cultured broth of fungal strain FKI-7792 by physicochemical screening. This strain was identified as a member of genus Neocosmospora based on morphology and UN A barcoding. The partially relative configuration of 1 was determined by C-13-NMR chemical shifts of the acetonide analog of 1. The absolute configuration was determined using an advanced Mosher's method. Compound 1 was assessed for anti-tumor, anti-microbial, and antimalarial activities, and its ability to scavenge or quench reactive oxygen species (ROS), such as superoxide anion radicals, hydroxy radicals and singlet oxygen (O-1(2)). Compound 1 showed a quenching effect on (O-1(2)) .