Switching Condensates: The CTD Code Goes Liquid
TRENDS IN BIOCHEMICAL SCIENCES(2020)
摘要
Condensates containing RNA polymerase II (Pol II) materialize at sites of active transcription. Young and coworkers now establish that C-terminal domain phosphorylation regulates Pol II partitioning into distinct condensates connected with transcription initiation or splicing. This advance hints that distinct condensates with specialized functional compositions might choreograph distinct stages of transcription.
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关键词
transcription,phase separation,RNA polymerase II,kinase,biophysics
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