Swimming Impacts On Pancreatic Inflammatory Cytokines, Mir-146a And Nf-Kappa B Expression Levels In Type -2 Diabetic Rats

Background: Obesity-induced chronic mflarmnation is a key component in the pathogenesis of insulin resistance and type-2 diabetesObjective: This study aimed to evaluate the effect of swimming exercise on pancreatic expression levels of inflammatory cytokines, miR-146a and NF-kappa B in type-2 diabetic male rats.Methods: Twenty-eight male Wistar rats were divided into four groups: contTol (Con), exercise, diabetes and diabetic exercise (n 7). Diabetes induction performed by the combination of high-fat diet (HFD. 4 weeks) and streptozotocin (35 mg/kg. ip). After induction of diabetes, the rats swain in the exercise groups for 12 weeks. Then blood and tissue samples were collected.Results: Our results indicated a significant increase in expression levels of miR-146. NF-kappa B and inflammatory cytokines (IL-6, INF-alpha, and IL-beta) while a significant decrease in pancreatic expression levels of TRAF6 and IRAK1 in diabetic group as compared to the control group. In contrast, swimming exercise resulted in a significant decrease in expression levels of miR-146a. NF-kappa B and inflammatory cytokines and a significant increase in expression levels of TRAF6 and IRAK1 in the exercise-diabetic group compared to the diabetic group.Conclusion: Our results indicated a significant increase in expression levels of nUR-146. NF-KB and inflammatory cytokines (IL-6. TNF-alpha, and IL-beta while a significant decrease in pancreatic expression levels of TRAF6 and IRAK1 in diabetic group as compared to the control group. In contrast, swimming exercise resulted in a significant decrease in expression levels of miR-146a. NF-kappa B and inflammatory cytokines and a significant increase in expression levels of TRAF6 and IRAK1 in the exercise-diabetic group compared to the diabetic group.