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Sema3A inhibits axonal regeneration of retinal ganglion cells via ROCK2.

Jieqiong Zhang,Wenyi Liu,Xi Zhang,Sen Lin,Jun Yan,Jian Ye

Brain Research（2020）

Cited 20|Views8
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Abstract
•Sema3A may negatively regulate axonal outgrowth in RGCs.•The suppressive role of Sema3A can be attenuated by blocking ROCK2.•Sema3A promotes phosphorylation of MLC2 during the optic nerve regeneration.
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Key words
Semaphorin3a (Sema3A),Retinal ganglion cells (RGC, RGCs),Rho-associated protein kinase 2 (ROCK2),Axonal regeneration
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