Sarcoidosis and calcium homeostasis disturbances-Do we know where we stand?
CHRONIC RESPIRATORY DISEASE(2019)
摘要
The majority of cases involving hypercalcemia in the setting of sarcoidosis are explained by the overproduction of calcitriol by activated macrophages. Vitamin D takes part in the regulation of granuloma formation. However, using vitamin D metabolites to assess the activity of the disease is still problematic, and its usefulness is disputable. In some cases, though, a calcium metabolism disorder could be a valuable tool (i.e. as a marker of extrathoracic sarcoidosis). Although sarcoidosis does not cause a decrease in bone mineral density, increased incidence of vertebral deformities is noted. Despite increasing knowledge about calcium homeostasis disorders in patients with sarcoidosis, there is still a need for clear guidelines regarding calcium and vitamin D supplementation in these patients.
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关键词
Sarcoidosis,calcium,vitamin D,hypercalcemia,hypercalciuria,calcitriol,1,25(OH)(2)D-3,25(OH)D-3
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