In Vitro and In Vivo Anti- Candida spp. Activity of Plant-Derived Products.

Candidiasis therapy, especially for candidiasis caused by non- species, is limited by the relatively reduced number of antifungal drugs and the emergence of antifungal tolerance. This study evaluates the anticandidal activity of 41 plant-derived products against species, in both planktonic and biofilm cells. This study also evaluates the toxicity and the therapeutic action of the most active compounds by using the model. The planktonic cells were cultured with various concentrations of the tested agents. The , , and essential oils as well as gallic acid were the most active anticandidal compounds. cell re-growth after treatment with these agents for 48 h demonstrated that the essential oil and gallic acid displayed fungistatic activity, whereas the and essential oils exhibited fungicidal activity. The essential oil was not toxic and increased the survival of worms infected with or . All the plant-derived products assayed at 250 µg/mL affected biofilms. The tested plant-derived products proved to be potential therapeutic agents against , especially non- species, and should be considered when developing new anticandidal agents.