Blood-brain barrier leakage of blood proteins in idiopathic normal pressure hydrocephalus.

Brain Research（2020）

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摘要

•BBB leakage of blood proteins was examined in iNPH and controls.•Light microscopy revealed fibrin(ogen) extravasation in iNPH.•Degree of fibrin(ogen) extravasation and astrogliosis was positively correlated.•Degree of fibrin(ogen) extravasation and aquaporin-4 and dystrophin-71 was correlated.•BBB dysfunction may be part of pathophysiology of iNPH.

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关键词

Blood-brain barrier dysfunction,Fibrinogen/fibrin extravasation,Dysfunction of capillaries,Impaired neurovascular unit,Astrogliosis,Neurodegeneration

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