Oncostatin-M-Reactive Pericytes Aggravate Blood-Brain Barrier Dysfunction by Activating JAK/STAT3 Signaling In Vitro.

Fuyuko Takata,Shinya Dohgu,Shinya Sakaguchi,Kenta Sakai,Gaku Yamanaka,Takuro Iwao,Junichi Matsumoto,Ikuya Kimura,Yume Sezaki,Yoshie Tanaka,Atsushi Yamauchi,Yasufumi Kataoka

Neuroscience（2019）

Cited 15|Views15

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Abstract

The present findings demonstrate that (1) pericytes can respond to OSM and (2) OSM-reactive pericytes aggravate OSM-induced RBEC barrier dysfunction. These indirect aggravating effects of OSM-reactive pericytes are likely due to activated JAK/STAT3 signaling in pericytes. In a previous study, OSM was shown to directly act on RBECs, impairing RBEC barrier function by activating JAK/STAT3 signaling. This is shown in the right endothelial cell, indicated by the dotted line in the bottom panel of this figure.

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Key words

ANOVA,BBB,BEC,BSA,CNS,DMSO,GAPDH,gp,IL,JAK,MMP,Na-F,NFκB,OSM,OSMR,PBS,RBEC,SDS,STAT,TEER,TJ

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