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Heat-killed probiotic regulates the body’s regulatory immunity to attenuate subsequent experimental autoimmune arthritis

Hai Jia,Shipu Ren, Xia Wang

Immunology Letters（2019）

Cited 15|Views0
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Abstract
•Pre-treating CIA mice with heat-killed L. reuteri reduced the severity of CIA.•Heat-killed L. reuteri might modulated serum IL-6 level to repress CIA development.•Tregs and IL-10-producing CD4 + T cells played a role in suppression of CIA response.•CD103+ DCs in MLN were expanded in recipients of heat-killed L. reuteri after CIA.•Treating with heat-killed L. reuteri did not provide benefits if CIA has emerged.
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Key words
Heat-killed probiotic,Arthritis,Regulatory immunity,Lactobacillus,Dendritic cells
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