Epileptiform activity promotes decreasing of Ca 2+ conductivity of NMDARs, AMPARs, KARs, and voltage-gated calcium channels in Mg 2+ -free model.

Sergei G Gaidin,Valery P Zinchenko,Ilia Y Teplov,Sultan T Tuleukhanov,Artem M Kosenkov

Epilepsy Research（2019）

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摘要

•The burst-firing pattern in Mg2+-free medium differs from spontaneous bursts.•The removal Mg2+ from the medium stimulates the release of glutamate.•Mg2+-free conditions cause decreased calcium conductivity of glutamate receptors.

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关键词

Epileptiform activity,NMDA receptors,AMPA receptors,Kainate receptors,Voltage-gated Ca2+-channels,Ca2+ conductivity

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