Melatonin ameliorates cerebral ischemia/reperfusion injury through SIRT3 activation.

Lili Liu,Hongping Chen,Jing Jin,Zhanbin Tang,Pengqi Yin,Di Zhong,Guozhong Li

Life Sciences（2019）

引用 48|浏览23

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摘要

•SIRT3 is downregulated with time after tMCAO.•Melatonin promotes SIRT3 expression after tMCAO.•Melatonin protects the brain from I/R damage and alleviates apoptosis via activation of the SIRT3 signaling pathway.

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关键词

Melatonin,SIRT3,Apoptosis,Ischemia-reperfusion injury

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