The 'Finnish new variant of Chlamydia trachomatis ' escaping detection in the Aptima Combo 2 assay is widespread across Norway, June to August 2019.

Tone Bjordal Johansen,Hilde Kløvstad,Rikard Rykkvin, Einar Bredo Herrfurth-Erichsen,Joakim Sorthe,Gro Njølstad,Marit Helen Ebbesen,Randi Monsen Nygaard, Ellen Kristin Sandmoen,Carina Thilesen, Annette Onken, Inger Liljedal,Ronza Hadad,Magnus Unemo

EUROSURVEILLANCE（2019）

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摘要

The 'Finnish new variant of Chlamydia trachomatis' (FI-nvCT), escaping detection in the Aptima Combo 2 assay (AC2), is widespread across Norway. From June to August 2019, 84% (81/97) of available AC2/Aptima CT discordant samples from five laboratories were confirmed as FI-nvCT. Two additional CT variants (CT 23S rRNA C1514T and G1523A) also escaped AC2 detection. The high FI-nvCT proportion might indicate a long-term national spread and it cannot be excluded that FI-nvCT emerged in Norway.

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关键词

Aptima Combo 2 assay,Chlamydia trachomatis,FI-nvCT,Norway,diagnostic escape

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