An Engineered Antibody Fragment Targeting Mutant Β-Catenin Via Major Histocompatibility Complex I Neoantigen Presentation

Michelle S. Miller,Jacqueline Douglass,Michael S. Hwang,Andrew D. Skora,Michael Murphy,Nickolas Papadopoulos,Kenneth W. Kinzler,Bert Vogelstein,Shibin Zhou,Sandra B. Gabelli

Journal of Biological Chemistry（2019）

Cited 18|Views75

Key words

beta-catenin,immunotherapy,major histocompatibility complex (MHC) class I,phage display,antibody engineering,catenin beta 1 (CTNNB1),human leukocyte antigen (HLA),neoantigen,MANAbody,cancer

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