HLA DR2b-binding peptides from human endogenous retrovirus envelope, Epstein-Barr virus and brain proteins in the context of molecular mimicry in multiple sclerosis
Immunology Letters(2020)
摘要
•Molecular basis for likely autoimmune origin of multiple sclerosis investigated.•Human endogenous retrovirus envelope and Epstein Barr virus proteins implicated.•Mimicry between brain and virus-derived proteins proposed.•HLA DR2b binding pairs of potential TH cell epitopes identified.•Modelling shows HLA DR2b binding similar to established TH cell epitope.
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关键词
ABP,βSYN,BLAST,CNS,EAE,EBV,EBNA1,env,HERV,IEDB,MAG,MBP,MOG,MS,MSRV,NCBI,OSP,PLP,SMM,SYN1,SYN2,TCR
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