Microstructure and biopharmaceutical performances of curcumin-loaded low-energy nanoemulsions containing eucalyptol and pinene: terpenes' role overcome penetration enhancement effect?

Ines Nikolic,Evgenia Mitsou,Ivana Pantelic,Danijela Randjelovic,Bojan Markovic,Vassiliki Papadimitriou,Aristotelis Xenakis,Dominique Jasmin Lunter,Ana Žugic,Snezana Savic

European Journal of Pharmaceutical Sciences（2020）

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摘要

The objective of this work was to develop low-energy nanoemulsions for enhanced dermal delivery of curcumin, using monoterpene compounds eucalyptol (EUC) and pinene (PIN) as chemical penetration enhancers.

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关键词

Monoterpene,Low-energy nanoemulsion,Electron paramagnetic resonance spectroscopy,Interfacial dynamics,Penetration,Curcumin

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