Estrogen receptor β activation ameliorates DSS-induced chronic colitis by inhibiting inflammation and promoting Treg differentiation

Di Guo,Xiaojing Liu,Cui Zeng,Ling Cheng,Gengqing Song,Xiaohua Hou,Liangru Zhu,Kaifang Zou

International Immunopharmacology（2019）

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摘要

•Circulating ERβ+CD4+ T cells might be a biomarker for evaluating disease severity of IBD.•ERβ activation significantly mitigated the DSS-induced chronic colitis.

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关键词

Inflammatory bowel disease,Estrogen receptor β,CD4+ T cell,Regulatory T cell

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