How presence of a signal peptide affects human galectins-1 and -4: Clues to explain common absence of a leader sequence among adhesion/growth-regulatory galectins.

Tanja J Kutzner,Alonso M Higuero,Martina Süßmair,Jürgen Kopitz,Michael Hingar,Natalia Díez-Revuelta,Gabriel García Caballero,Herbert Kaltner,Ingo Lindner,José Abad-Rodríguez,Dietmar Reusch,Hans-Joachim Gabius

Biochimica et Biophysica Acta (BBA) - General Subjects（2020）

引用 17|浏览29

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摘要

•Galectins-1 and -4 maintain activity when misdirected to the ER-Golgi route.•Galectins-1 and -4 become N-glycosylated at ER entry.•Misdirected galectins-1 and -4 differ in localization and secretion.•N-Glycosylation of galectins may disturb interactions and lattice formation.

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关键词

Glycosylation,Golgi,Lectin,Secretion,Signal peptide,Signal sequence

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