MSU Crystals induce sterile IL-1β secretion via P2X7 receptor activation and HMGB1 release.

Ygor Marinho,Camila Marques-da-Silva,Patricia Teixeira Santana,Mariana Martins Chaves, Augusto Shuiti Tamura, Thuany Prado Rangel, Isabel Virgínia Gomes-E-Silva,Marília Zaluar Passos Guimarães,Robson Coutinho-Silva

Biochimica et Biophysica Acta (BBA) - General Subjects（2020）

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摘要

•P2X7 receptor is involved with MSU-induced sterile inflammation.•MSU-induced IL1β secretion is dependent of P2X7 receptor.•MSU crystals induce HMGB1 release in P2X7 receptor-dependent manner.

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关键词

Sterile inflammation,Purinergic signaling,HMGB1,MSU crystals

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