Immunogenicity and protective efficacy of Burkholderia pseudomallei BLF1-N and BLF1-C terminal domains against BLF1 toxin.

Kunal Singh,Amit K Singh,Siva R Uppalapati,Joseph J Kingston,Manmohan Parida

International Immunopharmacology（2019）

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摘要

•Two truncated structural units, BLF1-C and BLF1-N were identified in BLF1 protein.•BLF1-C elicited comparatively elevated levels of cytokines and CD4+ /CD8+ T cells.•BLF1-C provided higher protection in mice against lethal challenge with BLF1 toxin.•We also report that BLF1 cause pathological changes in lungs, spleen and kidney.

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关键词

Burkholderia pseudomallei,Burkholderia lethal factor 1 (BLF1),BLF1-N domain,BLF1-C domain,Antibody,Protective efficacy

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