Inhibition of Ku70 in a high- glucose environment aggravates bupivacaine-induced dorsal root ganglion neurotoxicity.
Toxicology Letters（2020）
Abstract
•High glucose causes an increase in cell toxicity induced by BP.•High glucose aggravated BP-induced DNA damage and apoptosis.•High glucose aggravated BP-induced DNA damage through inhibit DNA-PK/Ku70 protein.
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Key words
DNA damage,DNA repair,Ku70,DRG,Neurotoxicity,Bupivacaine
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