Biomimetic Carriers Based on Giant Membrane Vesicles for Targeted Drug Delivery and Photodynamic/Photothermal Synergistic Therapy.

Membrane vesicles derived from live cells show great potential in biological applications due to their preserved cell membrane properties. Here we demonstrate that cell-derived giant membrane vesicles can be used as vectors to deliver multiple therapeutic drugs and carry out combinational phototherapy for targeted cancer treatment. We show that therapeutic drugs can be efficiently encapsulated into giant membrane vesicles and delivered to target cells by membrane fusion, resulting in synergistic photodynamic/photothermal therapy under light irradiation. This study highlights biomimetic giant membrane vesicles for drug delivery with potential biomedical application in cancer therapeutics.