Cp*Co III -catalyzed formal [4+2] cycloaddition of benzamides to afford quinazolinone derivatives.

Jingshu Yang, Xiao Hu,Zijie Liu,Xueyuan Li,Yi Dong,Gang Liu

CHEMICAL COMMUNICATIONS（2019）

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摘要

A Cp*Co-III-catalyzed arene C-H bond amidation/annulation of benzamides was developed to afford quinazolinone derivatives in one-pot with high yields and broad substrate scope. This method could be applied to the synthesis of quinazolinone drugs and late-stage modification of natural products.

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