Multidisciplinary rehabilitation reduces hypothalamic grey matter volume loss in individuals with preclinical Huntington's disease: A nine-month pilot study.

Danielle M Bartlett,Juan F Dominguez D,Alpar S Lazar,Catarina C Kordsachia,Tim J Rankin,Johnny Lo,Andrew D Govus,Brian D Power,Amit Lampit,Peter R Eastwood,Mel R Ziman,Travis M Cruickshank

Journal of the Neurological Sciences（2020）

引用 11|浏览9

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摘要

This exploratory study provides evidence that multidisciplinary rehabilitation can reduce hypothalamic volume loss and maintain peripheral BDNF levels in individuals with preclinical HD but may not impact on circadian rhythm. Larger, randomised controlled trials are required to confirm these findings.

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关键词

Hypothalamus,Brain-derived neurotrophic factor,Cortisol,Melatonin,Circadian rhythm,Sleep

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