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Mesenchymal stem cells transplanted with self-assembling scaffolds differentiated to regenerate nucleus pulposus in an ex vivo model of degenerative disc disease

Christina McKee,Naimisha Beeravolu,Christina Brown,Mick Perez-Cruet,G. Rasul Chaudhry

Applied Materials Today（2020）

Cited 12|Views13
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Abstract
•Self-assembling polymers for targeted delivery of cells.•Self-assembling scaffolds promoted mesenchymal stem cell differentiation in vitro.•Mesenchymal stem cells differentiated into nucleus pulposus-like cells ex vivo.•Ex vivo microenvironment stimulated regeneration of nucleus pulposus.
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ACAN,COL2,DDD,DM,DMMB,ECM,FBS,FOXF1,GM,H&E,IVD,K19,LBP,MSCs,NP,NPCs,PEG,PEG-4-Acr,PEG-4-SH,sGAG,SOX9
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