Pancreatogram: A Non-invasive Test that Allows an Encompassing View of the Exocrine-endocrine Pancreas Interaction

Purpose: The literature and our own research has put in evidence that between the two bullets in the barrell of the pancreatic revolver, the Langerhan islets and the pancreon units, evolve a subtle and significant interplay which revealed to be altered in glucose intolerant and diabetic patients. This type of approach, centered in the classical oral glucose tolerance test, gets an evident enhanced diagnostic value when to the measurement of glucose and insulin the blood values of the pancreon enzymes, such as amylase, pancreatic isoamylase, lipase and also calcium are added to each sample of the 2-hr test. A compeller feature that induced to pursue in this line of study was that a preliminary analysis confirmed that its information kept an undoubted coherence with the patient's clinical history and the collateral laboratory and imaging studies. The aim of this report is to put into consideration an outline of our findings in a control (C)group and in patients classified either as intolerant(I) or diabetics(D). Methods: Patients of both sexes 31-75 years of age, divided in three groups: C(n = 38); I (n = 32) and D(n = 19). Following a 12 hr fasting period, and after taking a venous blood sample,75 g of glucose dissolved in 375 ml of water was orally administered. Post ingestion venous samples,at 30, 60, 120 min were taken. Glycemia, amylasemia, pancreatic isoamylasemia, lipasemia and calcium were determined. The main emphasis was put in the cumulative value(C. V)(basal+30+60+120min) of each parameter. With the C.V, diagnostic indexes (D.I), resulting of the correlation of glycemia with the different exocrine enzymes and calcium,is also put into consideration. As it was considered suitable, either the ANOVA or a non-parametric test (Kruskal-Wallis) was also applied. Results: Tables N = 1 and 2. Conclusion: The analysis of the Tables reveal quite evidently that centering the results evaluation in the C.Vof each parameter clearly trigger a distinctive delineation of the insulo-pancreon-axis interaction. This makes easier the insertion of the patient in the appropiate group. Another undoubted improvement is that provided by the D.I. Appealing to all of them makes notoriously easier differentiate the C from the I group. There is no doubt that through a sequential testing of our here proposed Pancreatogram one is surely able to accurately establish if the patient under scrutiny keeps a stable functional insulo pancreon-axis condition, or, otherwise, is showing signs of either progressive deterioration or stimulating improvement.Table 1: Diagnostic indexesTable 2: 2hs Cumulative value