Association of IPMN with Other Non-pancreatic Cystic Lesions: Is it a Systemic Cystic Disorder?: 156

Purpose: To compare the incidence of liver and kidney cysts among patients with IPMN to an age and sex matched control group. Methods: In this study, computer tomography (CT) scans of 40 patients with surgically proven pancreatic IPMN were reviewed for presence of liver and kidney cysts. A control group of 40 patients undergoing CT scan for indications other than suspected pancreatic disease during the same time period were used for comparison. The demographic characteristics were collected among both groups. The continuous variables were compared by student t test and categorical variables by Fisher's Exact test. Results: IPMN and control groups had no age or gender differences (Table 1). The prevalence of liver and kidney cysts in IPMN patients was 20% and 63%, respectively. There was no statistical difference compared to controls (P>0.05), although multi-organ cysts were common in both groups.Table 1Conclusion: Based on the results of this small case-control study, it does not appear that patients with IPMN have any increased association with cystic lesions of the liver and kidneys. The pathogenesis of cyst formation in solid organs is not well understood. However, the formation of mucinous cysts such as IPMN and non-mucinous liver and kidney cysts are likely unrelated. This study is limited by a small sample size, but the incidence of extra-pancreatic cysts will be followed through an ongoing international IPMN registry.